Connect with us

Medical Research

Human cells that produce testosterone grown in the laboratory

Published

on

One way to grow human cells to produce testosterone in the laboratory was developed by a group of researchers at the University of Southern California Pharmacy School.

The researchers hope that with this method it will be possible to arrive at treatments to counteract low levels of testosterone in the body by using special personalized replacement cells, as reported by Vassilios Papadopoulos, a researcher who led the study.

The researchers transformed induced pluripotent stem cells, derived from human skin or blood, into Leydig cells, which are the cells present in human testes that produce the male sex hormone.
According to the researchers, Leydig’s cells grown in the laboratory looked the same as their real counterparts.

The low level of testosterone in men, also known as hypogonadism, can lead to fertility problems and to sexual function in general and can affect mood as well as conditions such as bone density and obesity.

The level of testosterone in the body is lowered naturally in the course of the age, however more or less sudden lowering can also be caused by infections such as mumps or by treatments for cancer during childhood or adolescence.

The main therapy is that which sees the intake of testosterone which can be applied as a gel or can be taken orally or injected.

“Leydig’s human cell transplant is just a few years away,” the researcher said.

William Stiff

A graduate of Georgia State University and a registered practitioner with the Physical Therapy Association of Georgia, William has held a long career as a physical therapist and has maintained a life-long interest in medical research and discovery. He writes for Health Shiner during his spare time, submitting a story whenever he comes across research that he feels is worth reporting. Outside of his career, William is also a passionate woodworker and painter.

3286 Heavner Avenue, Conyers Georgia, 30207
Ph: 770-785-5619
Email: [email protected]
William Stiff
Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Medical Research

Deaf people have “rewired” brains that influence learning according to a new study

Published

on

According to a new study published in Nature Scientific Reports, the brains of people with congenital deafness can develop differently and this can influence the ways in which these same people learn to learn. This study, according to the same researchers, may prove useful precisely to develop new methods of teaching “tailor-made” for all people who have never had the opportunity to use hearing during their existence.

According to Colin Johnson, a researcher at the College of Science of the State University of Oregon, people who are born deaf can have a life that is severely compromised even with regards to school and teaching in general. Often these people, in fact, as specified by the researcher, generally fail to reach an adequate level of education and this leads to cascade to other consequences that certainly do not improve the standard of living.

Researchers have discovered that it is a particular protein mutation that causes hearing loss and that it can also alter the wiring of different groups of neurons. The protein, known as otoferlina, has the sole task of encoding the sound in the sensory hair cells that are found in the inner ear.

If this protein undergoes a genetic modification, total hearing loss can occur. This mutation weakens the link between the protein and a calcium synapse in the ear and this lack of interaction is the basis of hearing loss.

Studying this protein in humans has always been difficult due to its size and due to the fact that it is characterized by low solubility. That is why Johnson and colleagues have studied zebrafish that share a similarity in genetic, molecular and cellular levels with humans.

Thanks to these studies, the researcher has discovered a smaller version of the otoferlina that could be used for gene therapy but only in those brains that have not yet undergone a complete rewiring such as that of adults.

“If you grow up without that protein, it’s not just a matter of replacing the gene. If you are deaf and grow deaf, it seems that the physical wiring of your brain is a little different. This complicates the goal of doing gene therapy. We need to go further and look at these hair cells and the brain itself. Does the brain process information differently? This is an area we need to focus on,” explains Johnson.

William Stiff

A graduate of Georgia State University and a registered practitioner with the Physical Therapy Association of Georgia, William has held a long career as a physical therapist and has maintained a life-long interest in medical research and discovery. He writes for Health Shiner during his spare time, submitting a story whenever he comes across research that he feels is worth reporting. Outside of his career, William is also a passionate woodworker and painter.

3286 Heavner Avenue, Conyers Georgia, 30207
Ph: 770-785-5619
Email: [email protected]
William Stiff
Continue Reading

Medical Research

Ghrelin can increase the urge to exercise according to a new discovery

Published

on

As some researchers have observed when performing experiments on mice, limiting access to food can increase the levels of a particular hormone, called ghrelin, and this in turn can increase the motivation to exercise, something that naturally leads, in a chain effect, slimming.

In the study, published in the Journal of Endocrinology, it is described how the increase in the level of this hormone pushed mice to voluntarily start exercising or physical activity. This finding, according to the same researchers, could lead, through the limitation of food intake or through the so-called “intermittent fasting,” overweight people to be encouraged to exercise more.

On the other hand, the restriction of food the same regular exercise are the two main ways and the most economic strategies to prevent and treat obesity, a sort of global “epidemic” that requires much more effective intervention strategies. However, adhering to a regular training regime can be difficult for many because motivation is lacking.

This hormone, also called the “hunger hormone,” can not only stimulate the appetite but, as demonstrated by Yuji Tajiri and colleagues from the Kurume University medical school, Japan, it can also stimulate the same desire to exercise. The mice genetically modified in the laboratory for not having ghrelin of their body, in fact, ran less than the control mice, which instead had normal ghrelin levels.

According to Tajiri, the results achieved by this study indicate “that hunger, which promotes ghrelin production, could also be involved in increasing motivation to voluntary exercise when nutrition is limited. Therefore, maintaining a healthy diet, with regular meals or fasting, could also encourage motivation for exercising in overweight people.”

William Stiff

A graduate of Georgia State University and a registered practitioner with the Physical Therapy Association of Georgia, William has held a long career as a physical therapist and has maintained a life-long interest in medical research and discovery. He writes for Health Shiner during his spare time, submitting a story whenever he comes across research that he feels is worth reporting. Outside of his career, William is also a passionate woodworker and painter.

3286 Heavner Avenue, Conyers Georgia, 30207
Ph: 770-785-5619
Email: [email protected]
William Stiff
Continue Reading

Medical Research

Exposure to sunlight can modify intestinal microbiome

Published

on

Exposure of the skin to ultraviolet light from the sun can modify the intestinal microbiome according to a new study published in Frontiers in Microbiology. To mediate this change would be vitamin D and this would also explain the protective effect of ultraviolet light itself with regard to inflammatory bowel diseases.

It is well known that exposure to sunlight gives greater production of vitamin D in the skin. It is known, however, through studies published in recent years, also that the same greater quantity of vitamin D can alter the human intestinal microbiome. It follows that solar radiation on the skin can change the human intestinal microbiome but this has only been shown in rodents. This new study shows that this effect is also real for humans.

The researchers performed experiments on 21 healthy volunteer women. The 21 patients underwent three one-minute ultraviolet exposure sessions throughout the body for a week. Throughout the treatment, stool samples were taken and intestinal bacteria were analyzed. Blood samples were also taken to analyze vitamin D levels. The researchers discovered that the exposure of the skin to ultraviolet rays significantly increased the intestinal microbial diversity and this happened only in those people who had not taken vitamin D supplements in the course of experiments.

As explained by Bruce Vallance, a researcher at the University of British Columbia who led the study, exposure to UVB rays increased the richness and uniformity of the subjects’ microbiome. Before exposure to rays, women who did not take supplements showed a less diversified intestinal microbiome than women who already took vitamin D supplements. Among the bacteria that increased the most were the Lachnospiraceae, a genus of bacteria already previously linked with vitamin D.

“UVB light is able to modulate the composition of the intestinal microbiome in humans, through the synthesis of vitamin D,” says Vallance. Now researchers would like to discover the underlying causes but according to Vallance, it is likely that exposure to UVB light somehow affects the immune system of the skin and this, in turn, has a favorable influence on the intestinal environment for different species of bacteria.

William Stiff

A graduate of Georgia State University and a registered practitioner with the Physical Therapy Association of Georgia, William has held a long career as a physical therapist and has maintained a life-long interest in medical research and discovery. He writes for Health Shiner during his spare time, submitting a story whenever he comes across research that he feels is worth reporting. Outside of his career, William is also a passionate woodworker and painter.

3286 Heavner Avenue, Conyers Georgia, 30207
Ph: 770-785-5619
Email: [email protected]
William Stiff
Continue Reading
September 2019
M T W T F S S
    Oct »
 1
2345678
9101112131415
16171819202122
23242526272829
30  

Trending

Copyright © 2019 Health Shiner