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Researchers reverse important symptom of schizophrenia in mice by manipulating genes

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This is an announcement of no small importance that appeared on the Columbia University website. The researchers say they have reversed one of the most important symptoms of schizophrenia in mice by reversing the SETD1A gene mutation, a gene already known and previously linked by other studies to schizophrenia. Specifically, the researchers reversed the impairment of spatial working memory.

For schizophrenia, there are currently no real treatments. This pathology, which influences the functioning of the brain as well as behavior and mood, must be linked to a sort of cognitive impairment. However, the drugs that exist today for schizophrenia mostly control the psychotic symptoms and not the cognitive ones. This new study shows that it is possible, in a sense, to repair brain cells made dysfunctional by schizophrenia, at least in mice, bringing their level of working memory back to a pre-existing state.

The study, published in Neuron, therefore shows what Joseph Gogos, a researcher at Columbia’s Brain Behavior Institute and senior author of the study, defines as a “promising path” to treat schizophrenia, particularly damage to working memory, not always treated with antipsychotic drugs. An inoperative working memory makes it difficult to maintain any kind of relationship and even damages everyday life by literally putting on by people with schizophrenia who can no longer interact with other people.

The researchers worked on the SETD1A gene. The latter produces a protein that can influence the activity of other important genes. The researchers worked on a group of memory-deficient mice, mice that had some difficulty, for example, in moving into a simple maze. These mice presented neurons from the different prefrontal cortex of normal mice. Specifically, mice lacking SETD1A had short and poorly developed neuronal branches.

This prevented them from establishing the necessary connections with other groups of brain neurons, as Jun Mukai, the study’s first author and former researcher in the Gogos laboratory, explains. By manipulating the SETD1A gene they discovered that it was linked to another gene, called LSD1. By inhibiting the latter, the memory of the mice greatly improved so that their axons began to grow again, becoming similar to those of healthy mice.

Researchers say SETD1A influences a number of other genes and proteins that, combined, can cause memory deficits. This finding could be useful, according to the researchers, to make personalized drugs for people with SETD1A gene mutations and, in a broader view, even to treat schizophrenia itself.

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
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Medical Research

Tobacco also linked to worse mental health according to a new study

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Often, when reference is made to the damage of cigarette smoking, mental health is hardly ever thought about, and yet cigarettes are also bad for you. This is suggested by a study by Professor Hagai Levine of the Hebrew University of Jerusalem published in PLOS ONE.

Levine and colleagues carried out a survey of 2000 Serbian university students from different social and economic backgrounds. The researchers found that students who smoked showed higher rates of clinical depression than their non-smoking peers, two to three times.

Taking into consideration only the students of the University of Pristina, the researchers found that 14% of the smoking students suffered from depression compared to 4% of the non-smoking peers, while for the University of Belgrade the percentages were 19% compared to 11% respectively.

The same students who smoked also showed lower mental health scores than non-smokers. According to Levine, this study adds further evidence that smoking and depression may be linked; although there is no direct evidence yet that smoking causes depression, it can be said that tobacco seems to have a non-positive effect on mental health.

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
Continue Reading

Medical Research

One can evaluate hearing quality by analyzing pupil dilation according to researchers

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It may prove to be a new and effective hearing test developed by a team of neuroscientists at the University of Oregon. According to a statement on the university’s website, it is possible to assess a person’s hearing level by measuring pupil dilation.

According to the same statement, this approach could be useful to understand the quality of hearing in infants, young adults with disabilities and adults with stroke or other diseases and in general in those people for whom direct responses are not possible. The researchers performed experiments on 31 adults by monitoring the size of their pupils with eye detection technology. The detection took place while the same people performed a hearing test and while staring at an object at a monitor.

The study, published in the Journal of the Association for Research in Otorhinolaryngology, explains that this system is inspired by a discovery made by the main author of the study, Avinash Singh Bala, 10 years ago when he noticed changes in the pupils of barn owls in response to unexpected noises in their natural environment.

“What we discovered was that pupil dilation was as sensitive as the button-press method,” Bala explains. “We had presented the first data analyses at the conferences and there was a lot of resistance to the idea that by using an involuntary response we could get results as good as the button-pressing data.”

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
Continue Reading

Medical Research

New peanut butter with probiotics developed by scientist

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A new peanut butter that allows you to acquire probiotic positives was developed by researcher Dan Perlman. Probiotics are microorganisms that live in the digestive system that help to promote digestion, produce important hormones and vitamins and generally strengthen the immune system.

For years, Perlman has been looking for new ways to “pack” probiotics into food to allow people to acquire them without using pills or third-party capsules. Probiotics need to be ingested alive to take advantage of their positive characteristics but if there is not enough water or other energy sources in the food to support these bacteria, they die quickly and are therefore useless once ingested.

Walnut butters seem to be unsuitable for cramming live probiotics as they contain very little water. However, the researcher noted that when freeze-dried peanut butter bacteria come in, the bacteria themselves remain “suspended” in a sort of deep sleep, still alive but ready to get back to work and “wake up” once they are ingested by people.

This is because they remain trapped in the structure of the fat matrix of these foods, a rather crystalline fat.

In the new peanut butter developed by the researcher, there are 500 million to one billion bacteria in a two-spoon portion, the amount of a probiotic pill.

Now the researcher himself is looking for a way to make this new peanut butter with probiotics for commercial use.

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
Continue Reading
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