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Diabetes: scientists discover new possible therapy to limit insulin collateral damage

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A protein that can act as a regulator of blood sugar and lipids under certain conditions has been identified by a group of researchers at the University of Geneva (UNIGE). The protein, called S100A9, could counteract the side effects of insulin given to diabetics.

The study, published in Nature Communications, mentions what could be a new treatment for diabetes and in general to significantly improve the quality of daily life of tens of millions of people. In fact, millions of people have to use insulin injections for both type 1 and type 2 diabetes. Any overdose can trigger hypoglycemia, the drop in blood glucose levels, while an overdose can lead to hyperglycemia.

By performing experiments on mice, the scientists found that by administering doses of S100A9 to diabetic deficient insulin-deficient rats, improved glucose management and better ketone and lipid control were achieved. They then discovered that this protein appears to work only when there is TLR4, a receptor placed on the membrane of certain cells, including adipocytes and cells of the immune system.

Now Roberto Coppari, one of the authors of the study together with Giorgio Ramadori, intends to understand with his team how the S100A9 protein works. In this regard, they are devising a new treatment that combines low doses of insulin and S100A9 to determine whether glucose and ketones can be better controlled and limit the same negative side effect as insulin.

“We also want to decipher the exact role of TLR4 in order to offer a therapeutic strategy that achieves the delicate balance between optimal blood glucose, ketones and lipid control,” explains Coppari himself.

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
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Medical Research

Tobacco also linked to worse mental health according to a new study

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Often, when reference is made to the damage of cigarette smoking, mental health is hardly ever thought about, and yet cigarettes are also bad for you. This is suggested by a study by Professor Hagai Levine of the Hebrew University of Jerusalem published in PLOS ONE.

Levine and colleagues carried out a survey of 2000 Serbian university students from different social and economic backgrounds. The researchers found that students who smoked showed higher rates of clinical depression than their non-smoking peers, two to three times.

Taking into consideration only the students of the University of Pristina, the researchers found that 14% of the smoking students suffered from depression compared to 4% of the non-smoking peers, while for the University of Belgrade the percentages were 19% compared to 11% respectively.

The same students who smoked also showed lower mental health scores than non-smokers. According to Levine, this study adds further evidence that smoking and depression may be linked; although there is no direct evidence yet that smoking causes depression, it can be said that tobacco seems to have a non-positive effect on mental health.

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
Continue Reading

Medical Research

One can evaluate hearing quality by analyzing pupil dilation according to researchers

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It may prove to be a new and effective hearing test developed by a team of neuroscientists at the University of Oregon. According to a statement on the university’s website, it is possible to assess a person’s hearing level by measuring pupil dilation.

According to the same statement, this approach could be useful to understand the quality of hearing in infants, young adults with disabilities and adults with stroke or other diseases and in general in those people for whom direct responses are not possible. The researchers performed experiments on 31 adults by monitoring the size of their pupils with eye detection technology. The detection took place while the same people performed a hearing test and while staring at an object at a monitor.

The study, published in the Journal of the Association for Research in Otorhinolaryngology, explains that this system is inspired by a discovery made by the main author of the study, Avinash Singh Bala, 10 years ago when he noticed changes in the pupils of barn owls in response to unexpected noises in their natural environment.

“What we discovered was that pupil dilation was as sensitive as the button-press method,” Bala explains. “We had presented the first data analyses at the conferences and there was a lot of resistance to the idea that by using an involuntary response we could get results as good as the button-pressing data.”

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
Continue Reading

Medical Research

New peanut butter with probiotics developed by scientist

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A new peanut butter that allows you to acquire probiotic positives was developed by researcher Dan Perlman. Probiotics are microorganisms that live in the digestive system that help to promote digestion, produce important hormones and vitamins and generally strengthen the immune system.

For years, Perlman has been looking for new ways to “pack” probiotics into food to allow people to acquire them without using pills or third-party capsules. Probiotics need to be ingested alive to take advantage of their positive characteristics but if there is not enough water or other energy sources in the food to support these bacteria, they die quickly and are therefore useless once ingested.

Walnut butters seem to be unsuitable for cramming live probiotics as they contain very little water. However, the researcher noted that when freeze-dried peanut butter bacteria come in, the bacteria themselves remain “suspended” in a sort of deep sleep, still alive but ready to get back to work and “wake up” once they are ingested by people.

This is because they remain trapped in the structure of the fat matrix of these foods, a rather crystalline fat.

In the new peanut butter developed by the researcher, there are 500 million to one billion bacteria in a two-spoon portion, the amount of a probiotic pill.

Now the researcher himself is looking for a way to make this new peanut butter with probiotics for commercial use.

Johnathan Flint

Johnathan is a recent graduate of the Missouri University of Science and Technology with a Bachelor of Medicine, and is an avid reader of numerous medical journals. He recently joined Health Shiner as an editor, researcher and content contributor, and brings a great deal of knowledge and wisdom to our reporting.

2462 White Oak Drive, Weston Missouri, 64098
Ph: 816-640-5682
Email: [email protected]
Johnathan Flint
Continue Reading
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