Deaf people have “rewired” brains that influence learning according to a new study

According to a new study published in Nature Scientific Reports, the brains of people with congenital deafness can develop differently and this can influence the ways in which these same people learn to learn. This study, according to the same researchers, may prove useful precisely to develop new methods of teaching “tailor-made” for all people who have never had the opportunity to use hearing during their existence.

According to Colin Johnson, a researcher at the College of Science of the State University of Oregon, people who are born deaf can have a life that is severely compromised even with regards to school and teaching in general. Often these people, in fact, as specified by the researcher, generally fail to reach an adequate level of education and this leads to cascade to other consequences that certainly do not improve the standard of living.

Researchers have discovered that it is a particular protein mutation that causes hearing loss and that it can also alter the wiring of different groups of neurons. The protein, known as otoferlina, has the sole task of encoding the sound in the sensory hair cells that are found in the inner ear.

If this protein undergoes a genetic modification, total hearing loss can occur. This mutation weakens the link between the protein and a calcium synapse in the ear and this lack of interaction is the basis of hearing loss.

Studying this protein in humans has always been difficult due to its size and due to the fact that it is characterized by low solubility. That is why Johnson and colleagues have studied zebrafish that share a similarity in genetic, molecular and cellular levels with humans.

Thanks to these studies, the researcher has discovered a smaller version of the otoferlina that could be used for gene therapy but only in those brains that have not yet undergone a complete rewiring such as that of adults.

“If you grow up without that protein, it’s not just a matter of replacing the gene. If you are deaf and grow deaf, it seems that the physical wiring of your brain is a little different. This complicates the goal of doing gene therapy. We need to go further and look at these hair cells and the brain itself. Does the brain process information differently? This is an area we need to focus on,” explains Johnson.

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