Eating less prolongs life and counteracts aging in mice

You have to eat less food if you want to reduce inflammation in the body and generally live longer: this is basically the conclusion of a new study that appeared in Cell.
The research clearly speaks of “caloric restrictions” in terms of benefits to the body following experiments carried out on mice on low-calorie diets.
It is not the first research that shows that eating less lengthens life substantially, but it is the first study that shows that calorie restrictions have influences at the level of individual cells and tissues, as explained by Juan Carlos Izpisua Belmonte, senior author of the study.
This information could be used to synthesize new drugs to treat all those diseases related to aging.

During the experiments, the researchers compared the reactions of rats that consumed 30% less calories than the traits of another group. Calorie restrictions were imposed on rats in the first group from the age of 18 months to 27 months (an age comparable to 50 to 70 years for humans).

By isolating 40 cell types in the experimental rats, cells from various parts of the body such as fat tissue, kidneys, skin, liver, bone marrow, brain, etc., and genetically sequencing the cells, the researchers noticed changes that occurred as a result of aging in rats following a normal diet.

In caloric restriction rats, these changes did not occur and many tissues and cells continued to resemble those of young rats.
In general, 57% of the age-related changes in cell composition observed in the tissues of rats on a normal diet did not occur in calorie-restricted rats.

The cells and genes most affected by caloric restriction were those related to immunity, inflammation and lipid metabolism. In rats that ate less, the number of immune cells was not affected by aging.
For example, in brown adipose tissue, calorie restriction restored the expression levels of many anti-inflammatory genes.

According to Jing Qu, an author of the study and professor at the Chinese Academy of Sciences, the main result behind this study is that the inflammatory response linked to the onset of aging could be suppressed, even in humans, by caloric restriction.

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