Oral anticoagulant drug retards progression of Alzheimer’s disease in mice

A group of researchers has discovered that the use of a particular drug that acts as an oral anticoagulant, dabigatran, can delay the appearance of Alzheimer’s disease in mice. The research was carried out by scientists from the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Rockfeller University of New York while the study was published in the Journal of the American College of Cardiology .

According to the researchers, long-term anticoagulation with dabigatran effectively slowed the progression of Alzheimer’s disease in mice during experiments. Marta Cort├ęs Canteli, a researcher at the CNIC and one of the authors of the study, speaks of an “important progress” regarding effective treatments for Alzheimer’s disease.

To defeat this disease, according to the researcher, there will be a need for personalized therapies aimed at various and different processes that can contribute to the progression of the disease. Among the objectives there is, according to the researcher, cerebral circulation and precisely to treat the latter an oral anticoagulant such as dabigatran can have an effective approach for those Alzheimer’s patients who have a tendency to coagulation.

According to the researcher, in addition to other studies that will have to certify the beneficial action of this drug, there will also be a need to create new diagnostic tools to identify Alzheimer’s patients with a tendency to coagulation with greater precision and efficiency, and precisely this “will be an important research line in the coming years.”

Mushroom consumption linked to lower risk of prostate cancer

Mushroom consumption could be linked to a lower risk of prostate cancer according to a new study published in the International Journal of Cancer . The researchers used data from 36,000 Japanese men who covered several decades, ranging in age from 40 to 79 years. These men came from the Miyagi and Ohsaki areas of Japan.

The data were also collected thanks to questionnaires that included questions such as those related to the consumption of mushrooms or other particular foods, as well as questions related to physical activity and personal and family medical conditions.

Researchers discovered a link between regular mushroom consumption and a reduction in prostate cancer risk in men and this link was even more significant for men aged 50 and over and in those men where the diet was mainly made from meat and dairy products with limited consumption of vegetables and fruit.

“Although our study suggests that regular consumption of mushrooms can reduce the risk of prostate cancer, we also want to emphasize that a healthy and balanced diet is much more important than filling the trolley with mushrooms,” Shu Zhang says. Zhang is a professor of epidemiology at the Tohoku University as well as lead author of the study

Zhang adds that in the past, test-tube studies and studies on living organisms had shown that fungi can potentially prevent prostate cancer.

According to the researcher, this is to be explained by the good amount of vitamins, minerals and antioxidants present in mushrooms, in particular L-ergotionein. The latter regulates the cellular imbalance caused by unsound dietary choices and long-term exposure to environmental toxins.

Zhang himself admits that new research is needed to understand the extent of this connection also because this study was carried out only on a limited population.

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